Eddie Jones'England will be hoping to secure the Triple Crown when they face Wayne Pivac's Wales on Saturday.
The Red Rose haven't achieved this feat since 2016 and it will provide added motivation against the 2019 Grand Slam winners.
Wales have faltered in recent games, losing 24-14 to Ireland in Dublin before falling to a 23-27 home defeat at the hands of the French in their last outing.
The Welsh will be looking to bounce back and win at Twickenham for the first time in five years.
But what channel is the match on?
Here's all the information you will need…
When is England v Wales?
The game will be played on Saturday March 7 at Twickenham Stadium.
Kick off is scheduled for 4.45pm.
What TV channel is the match on?
The Guinness Six Nations match between England and Wales will be broadcast on ITV1, with coverage starting at 3.50pm.
Can you live stream the match?
If you are in the UK, you will be able to live stream the game on the ITV Hub.
What is the Triple Crown?
The Triple Crown is competed for by the home nations – England, Ireland, Scotland and Wales.
It is awarded when one of these nations manages to beat the other three during the Six Nations competition.
England have thus far beaten Scotland and Ireland and will be awarded the trophy if they beat Wales on Saturday.
Sam Underhill, whose miracle tackle won the match for England on Wales’ last Six Nations visit to Twickenham, has been forced out of Saturday’s clash by injury.
Eddie Jones turns instead to Mark Wilson, who has started just one Premiership match since the World Cup due to injury. The one other change sees Anthony Watson replace Jonathan Joseph on the wing.
Wales have named Dan Biggar in their starting XI despite concerns over a knee injury picked up last weekend.
Liam Williams and Josh Navidi have also been handed starting berths after shaking off their own injury issues.
What are the odds?
Odds courtesy of thepools.com
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