Prime Minister Boris Johnson has announced further Covid-19 restrictions, plunging millions into a Tier 4 lockdown.
The new restrictions will come into effect from Sunday morning in the most affected areas in London, the South East and the East of England, with non-essential retail closing and people told they must work from home if they can.
As a result of the new Tier 4, London's Premier League clubs will not be allowed to have fans in attendance after briefly being able to welcome them back.
Arsenal, Chelsea, Tottenham Hotspur, Crystal Palace, Fulham and West Ham United are all affected by the changes.
Players will need to be extra careful when away from training and match days and ensure that they stick to the relevant protocols.
Coronavirus testing will be as rigorous as ever, especially for London teams, with Newcastle United recently suffering an outbreak at their training ground.
A number of players tested positive for the virus and their game against Aston Villa was postponed as a result.
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The Premier League will be hopeful that there are no more outbreaks or postponements but, given the situation, further disruption to the fixture schedule may be inevitable.
Speaking at a press conference on Saturday, Johnson explained how a new variant of the virus has emerged which is believed to be up to 70% more transmissible.
"Christmas this year will be different, very different," he said. "We're sacrificing the chance to see our loved ones this Christmas so that we have a better chance of protecting their loves, so that we can see them at future Christmases.
"And as sure as night follows day we will beat this virus, we'll defeat it and reclaim our lives."
He added: "We, of course, bitterly regret the changes that are necessary but, alas, when the facts change you have to change your approach.
"The briefing that I had yesterday about this mutation of the virus, particularly about the speed of transmission, was not possible to ignore."
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